ProteinDT

A Text-guided Protein Design Framework
Nature Machine Intelligence 2025

¹University of California Berkeley
²California Institute of Technology
³University of Toronto
⁴University of Wisconsin-Madison
⁵Morgridge Institute for Research
⁶Université de Montréal
⁷Mila
⁸Texas A&M University
⁹Nvidia Research
¹⁰Argonne National Laboratory
¹¹HEC Montréal
¹²National Research Council Canada

^♦Equal advising

Text-guided Peptide Editing for PDB-3IQI.

ProteinDT pretraining and downstream pipeline

ProteinDT editing results

Citation

@article{liu2025text,
    title={A text-guided protein design framework},
    author={Liu, Shengchao and Li, Yanjing and Li, Zhuoxinran and Gitter, Anthony and Zhu, Yutao and Lu, Jiarui and Xu, Zhao and Nie, Weili and Ramanathan, Arvind and Xiao, Chaowei and others},
    journal={Nature Machine Intelligence},
    pages={1--12},
    year={2025},
    publisher={Nature Publishing Group UK London}
}